Humanin
Mitochondrial-encoded peptide with cytoprotective effects in neurons.
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Mitochondrial-encoded peptide with cytoprotective effects in neurons.
Evidence Intelligence Score™
- Preclinical← current
- Pilot human
- RCT
- Multi-RCT
- Meta-analysis
Confidence aggregates eight dimensions of evidence — human data, safety maturity, mechanism, clinical readiness, momentum, consistency, long-term follow-up, and translational signal. It is a measure of what is known, not a recommendation. Methodology.
- Human evidenceWeight of RCT and observational data3.8
- Safety maturityFollow-up depth and adverse-event signal3.0
- Mechanism confidencePathway specificity and clarity6.0
- Clinical readinessDistance to physician-prescribable use2.8
- Research momentumRecency of indexed clinical evidence5.0
- Study consistencyEffect direction across cohorts3.0
- Long-term dataFollow-up beyond initial trial windows1.8
- Translational confidenceAnimal → human signal preservation4.3
Mechanistic and preclinical evidence is suggestive; controlled human trials are not yet on the index.
Translational confidence is limited until pre-registered human trials reproduce the preclinical signal.
Interactions outside listed contraindications, long-term safety, and effect heterogeneity across age and sex are not fully resolved.
Outlook: speculative. A grade upgrade requires controlled human evidence, not additional preclinical confirmation.
- —Long-term safety beyond reported study durations.
- —Effect size in populations under-represented in the cited trials.
- —Interactions with concomitant medications outside listed contraindications.
We surface uncertainty next to every claim. Suggestive, never prescriptive — discuss with a clinician.