How we grade evidence.
Every reported use on this site carries an evidence grade. The grade reflects the strength of human data supporting that specific use — not a marketing score, not an aggregate of opinions.
Human RCT evidence
AHuman RCT evidenceAt least one randomized controlled trial in humans with a primary outcome relevant to the reported use. Higher weight given to pre-registered trials and replication.
Human observational
BHuman observationalCohort, case-control, registry, or open-label human data. Useful for safety signals and real-world dose ranges but cannot establish causality.
Preclinical only
CPreclinical onlyAnimal models, in-vitro work, or mechanistic studies. Treated as hypothesis-generating; human translation is uncertain.
Anecdotal
DAnecdotalUser reports, forum posts, clinician opinion. Surfaced for completeness and labelled clearly as anecdotal.
Independent. Transparent. Non-commercial.
- — No affiliate revenue on substance, brand, or comparison pages.
- — Every claim is paired with the limitations and unknowns we are aware of.
- — The data export and audit log are public; corrections are versioned.
- — We do not recommend a dose. We surface what is reported and grade the evidence behind it.
Grades summarize evidence quality, not magnitude of effect. A peptide can carry a Grade A and still have a small clinical effect; another can carry Grade C and have a large but uncertain one. Always read the underlying citations and discuss with a clinician.