Peptide MedixAdipotide (FTPP)
Peptidomimetic FTPP conjugate studied in adipose-vasculature targeting models
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Adipotide, also written FTPP (fat-targeted proapoptotic peptide), is a synthetic peptidomimetic built from two functional halves joined into a single molecule. One half is a cyclic nine-residue homing motif, CKGGRAKDC, identified by phage-display screening as a binder of a prohibitin-1 / annexin A2 complex reported on the endothelium of white adipose tissue. The other half is D(KLAKLAK)2, an amphipathic sequence assembled from D-amino acids that disrupts mitochondrial membranes once it reaches the inside of a cell. The design intent described in the literature is address-plus-payload: the homing motif supplies vascular selectivity, the effector domain supplies the activity.
- Peptide
- Adipotide
- Strength
- 2 mg
- Package
- 2 mg
- Purity
- ≥99%
- Form
- vial
