Peptide Medix5-Amino-1MQ
Small-molecule NNMT inhibitor for adipocyte and NAD metabolism research.
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5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), not a peptide. NNMT transfers a methyl group from S-adenosylmethionine to nicotinamide, producing 1-methylnicotinamide and consuming both a methyl donor and a precursor that would otherwise feed NAD-plus salvage. Because the enzyme is markedly overexpressed in adipose tissue in research models, blocking it became an obvious way to test whether that methylation flux is a driver of metabolic slowdown or merely a marker of it. The compound is a quinolinium species, supplied as its iodide salt, and the permanently charged cationic core is the feature that shapes how researchers use it. Published work has centered on adipocyte cultures, where investigators measure intracellular NAD-plus, sirtuin activity, lipolysis and mitochondrial function after NNMT inhibition, and on rodent diet-induced obesity models examining fat-pad mass and metabolic markers. It is also used as a chemical probe when NNMT's role in a given tissue is uncertain.
- Peptide
- 5-Amino-1MQ
- Strength
- 50 mg
- Package
- 50 mg
- Purity
- ≥99%
- Form
- vial
