BioGenix PeptidesIGF-1LR3 1mg
Insulin-like Growth Factor-1 Long Arg3 (IGF-1 LR3) is a synthetic analog of human IGF-1 designed with a modified amino acid sequence to improve stability and extend half-life.
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Insulin-like Growth Factor-1 Long Arg3 (IGF-1 LR3) is a synthetic analog of human IGF-1 designed with a modified amino acid sequence to improve stability and extend half-life. It differs from native IGF-1 by the substitution of arginine for glutamic acid at position 3, along with an additional 13-amino-acid extension at the N-terminus. These modifications reduce binding affinity to IGF-binding proteins (IGFBPs), which normally sequester circulating IGF-1, thereby increasing bioavailability in experimental models. Native IGF-1 is a 70 amino acid peptide hormone primarily secreted by the liver in response to growth hormone (GH). IGF-1 LR3 was engineered to overcome IGF-1’s short half-life and rapid inactivation, resulting in extended half-life (20–30 hours vs. 20–30 minutes for native IGF-1), reduced binding to IGFBPs, leading to greater receptor activation, and enhanced potency in in vitro and in vivo models of cell growth and metabolism.
- Peptide
- IGF-1 LR3
- Strength
- 1 mg
- Package
- 1 mg
- Purity
- Ultra-Pure Series™
- Form
- vial
